Difference between revisions of "Moclobemide-escitalopram"

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* '''Day 9:''' start escitalopram in a normal dosage of 10 mg/day.
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* Caution is necessary, because occurrence of the serotonin syndrome is theoretically possible.
 
* Caution is necessary, because occurrence of the serotonin syndrome is theoretically possible.
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Revision as of 08:59, 20 June 2016

Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide
Escitalopram
Type Antidepressant
Group SSRI
links
Medscape Escitalopram
PubChem 10832572
PubMed Escitalopram
Kompas (Dutch) Escitalopram
Wikipedia Escitalopram

Switch medication from moclobemide to escitalopram.[1] [2]

Nietinrijdenbord.png Stop moclobemide
  • Decrease with about 25% of original dose every 3 days
  • Stop and wait for about 24 hour as a washout period
Eenrichtingbord.png Start escitalopram
  • Start with the initial dose
Infobord.png More information
  • Caution is necessary, because occurrence of the serotonin syndrome is theoretically possible.
  • Because of the short half life of moclobemide (approx. 2h), the next antidepressant can start next day after stopping with moclobemide.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Keks, Nicholas, J. Hope, and S. Keogh. "Switching and stopping antidepressants." Australian Prescriber 39.3 (2016).
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