Difference between revisions of "Moclobemide-fluoxetine"

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| to = fluoxetine
 
| to = fluoxetine
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
+
{{stopMoclobemide}}
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
 
* '''Day 8:''' stop administration of moclobemide.
 
 
| start =   
 
| start =   
* '''Day 8-9:''' a wash-out period of two days is necessary.
+
* '''Day 9:''' start fluoxetine in a normal dosage of 20 mg/day.
* '''Day 10:''' start fluoxetine after this period in a normal dosage of 20 mg/day.
 
 
| info =  
 
| info =  
 
* Caution is necessary, because occurrence of serotonin syndrome is theoretically possible.
 
* Caution is necessary, because occurrence of serotonin syndrome is theoretically possible.
|info=
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{{Shortt1/2}}
{{review}}
 
 
}}
 
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Revision as of 13:44, 14 October 2015

Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide
Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine

Switch medication from moclobemide to fluoxetine.[1] [2]

Nietinrijdenbord.png Stop moclobemide
  • Before day 1: gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
  • Day 1: reduce the dosage of moclobemide to 150 mg/day.
  • Day 8: stop administration of moclobemide.
Eenrichtingbord.png Start fluoxetine
  • Day 9: start fluoxetine in a normal dosage of 20 mg/day.
Infobord.png More information
  • Caution is necessary, because occurrence of serotonin syndrome is theoretically possible.
  • Because of short halve life of moclobemide after stopping, the next antidepressant can start next day.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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