Difference between revisions of "Moclobemide-fluoxetine"

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| to = fluoxetine
 
| to = fluoxetine
 
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| stop =  
* '''Before day 0:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
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{{generaldecrease25p3d}}
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
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{{24Hwashout}}
* '''Day 8:''' stop administration of moclobemide.
 
 
| start =   
 
| start =   
* '''Day 8-9:''' a wash-out period of two days is necessary.  
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{{generalstart}}
* '''Day 10:''' start fluoxetine after this period in a normal dosage of 20 mg/day.}}
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| info =
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* Caution is necessary, because occurrence of serotonin syndrome is theoretically possible.
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{{mocloshorthalflife}}
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}}

Revision as of 09:02, 20 June 2016

Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide
Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine

Switch medication from moclobemide to fluoxetine.[1] [2]

Nietinrijdenbord.png Stop moclobemide
  • Decrease with about 25% of original dose every 3 days
  • Stop and wait for about 24 hour as a washout period
Eenrichtingbord.png Start fluoxetine
  • Start with the initial dose
Infobord.png More information
  • Caution is necessary, because occurrence of serotonin syndrome is theoretically possible.
  • Because of the short half life of moclobemide (approx. 2h), the next antidepressant can start next day after stopping with moclobemide.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Keks, Nicholas, J. Hope, and S. Keogh. "Switching and stopping antidepressants." Australian Prescriber 39.3 (2016).
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