Moclobemide-fluoxetine

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Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide
Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine

Switch medication from moclobemide to fluoxetine.

Nietinrijdenbord.png Stop moclobemide
  • Before day 1: gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
  • Day 1: reduce the dosage of moclobemide to 150 mg/day.
  • Day 8: stop administration of moclobemide.
Eenrichtingbord.png Start fluoxetine
  • Day 9: start fluoxetine in a normal dosage of 20 mg/day.
Infobord.png More information
  • Caution is necessary, because occurrence of serotonin syndrome is theoretically possible.
  • Because of short halve life of moclobemide after stopping, the next antidepressant can start next day.
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