Switch medication from moclobemide to fluoxetine.
- Decrease with about 25% of original dose every 3 days
- Stop and wait for about 24 hour as a washout period
- Start with the initial dose
- Caution is necessary, because occurrence of serotonin syndrome is theoretically possible.
- Because of the short half life of moclobemide (approx. 2h), the next antidepressant can start next day after stopping with moclobemide.
- Keks, Nicholas, J. Hope, and S. Keogh. "Switching and stopping antidepressants." Australian Prescriber 39.3 (2016).
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