Moclobemide-venlafaxine

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Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide
Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine

Switch medication from moclobemide to venlafaxine.[1] [2]

Nietinrijdenbord.png Stop moclobemide
  • Gradually reduce dosage of moclobemide to a maximum of 300 mg/ day.
  • When a dosage of 300 mg/day is reached, stop administration.
Eenrichtingbord.png Start venlafaxine
  • Day 1-2: a wash-out period of two days is necessary.
  • Day 3: start venlafaxine after this period in a normal dosage of 75 mg/day.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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