Difference between revisions of "Nortriptyline-amitriptyline"

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| to = amitriptyline   
 
| to = amitriptyline   
 
| stop =  
 
| stop =  
* Gradually reduce dosage of nortriptylin to a maximum of 50 mg/day.
+
{{TCAdecrease25p3d}}
* When a dosage of 50 mg/day is reached, stop administration.
 
 
| start =  
 
| start =  
* No wash-out period is needed.
+
*Simultaneously, at the same time of the decrease
* Start administration of amitriptyline the next day in a normal dosage of 50-100 mg/day.
+
{{TCAincrease25p3d}}
 
| info =
 
| info =
* Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose
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* {{TCAantichol}}
 
}}
 
}}

Revision as of 09:56, 22 September 2016

Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from nortriptyline to amitriptyline.[1] [2]

Nietinrijdenbord.png Stop nortriptyline
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start amitriptyline
  • Simultaneously, at the same time of the decrease
  • Day 1: Increase with about 25% of target dose per 3 days.
Infobord.png More information
  • Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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