| to = duloxetine
| stop =
* '''Before day 0:''' gradually reduce dosage of nortriptyline to a maximum of 50 mg/day.* '''Day 1:''' reduce dosage of nortriptyline to 25 mg/day.* '''Day 3:''' reduce dosage of nortriptyline to 10 mg/day.{{TCAdecrease25p3d}}| start = * '''Day 1:''' simultaneously start administration of duloxetine in a normal dosage of 60 mg/day.* '''Day 8:''' stop administration of nortriptyline and continue administration of duloxetine.{{StartAntidepressant}}| info = * Duloxetine is a inhibitor of CYP2D6, which metabolizes nortriptyline.Safe target dose duloxetine = 60 mg
}}