Nortriptyline-maprotiline

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Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline
Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline

Switch medication from nortriptyline to maprotiline.[1] [2]

Nietinrijdenbord.png Stop nortriptyline
  • Gradually reduce dosage of nortriptylin to a maximum of 50 mg/day.
  • When a dosage of 50 mg/day is reached, stop administration.
Eenrichtingbord.png Start maprotiline
  • No wash-out period is needed.
  • Start administration of maprotiline the next day in a normal dosage of 25-75 mg/day.
Infobord.png More information
  • Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
  • Actually maprotiline is a TCA with a carbon bridge, so it is also called TetraCyclicAntidepressant.
  • This switch is currently being reviewed.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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