Difference between revisions of "Nortriptyline-mirtazapine"

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| to = mirtazapine  
 
| to = mirtazapine  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of nortriptyline to a maximum of 50 mg/day.
+
{{StopNortriptyline}}
* '''Day 1:''' reduce dosage of nortriptyline to 25 mg/day.
 
* '''Day 3:''' reduce dosage of nortriptyline to 10 mg/day.
 
 
| start =  
 
| start =  
 
* '''Day 1:''' simultaneously start administration of mirtazapine in a normal dosage of 30 mg/day.
 
* '''Day 1:''' simultaneously start administration of mirtazapine in a normal dosage of 30 mg/day.
 
* '''Day 8:''' stop administration of nortriptyline and continue administration of mirtazapine.
 
* '''Day 8:''' stop administration of nortriptyline and continue administration of mirtazapine.
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{{review}}
 
  
 
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Revision as of 16:27, 28 October 2015

Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline
Mirtazapine
Type Antidepressant
Group other
links
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine

Switch medication from nortriptyline to mirtazapine.[1] [2]

Nietinrijdenbord.png Stop nortriptyline
  • Before day 1: gradually reduce dosage of nortriptyline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
  • Day 1-3: reduce dosage of nortriptyline to 25 mg/day.
  • Day 4-7: reduce dosage of nortriptyline to 10 mg/day.
  • Day 8: stop administration of nortriptyline.
Eenrichtingbord.png Start mirtazapine
  • Day 1: simultaneously start administration of mirtazapine in a normal dosage of 30 mg/day.
  • Day 8: stop administration of nortriptyline and continue administration of mirtazapine.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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