Nortriptyline-vortioxetine

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Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline
Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine

Switch medication from nortriptyline to vortioxetine.[1] [2]

Nietinrijdenbord.png Stop nortriptyline
  • Day 1: reduce dosage to 50%.
  • Day 8: stop
Eenrichtingbord.png Start vortioxetine
  • No wash-out period is needed.
  • Day 9: start administration of vortioxetine in a normal dosage of 10 mg/day.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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