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Olanzapine LA-Paliperidone

Olanzapine
long acting
Type Antipsychotic
Group Atypical AP
links
Medscape Olanzapine
EMEA zypadhera
PubChem 4585
PubMed Olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine
Paliperidone
Type Antipsychotic
Group Atypical AP
links
Medscape Paliperidone
EMEA invega
PubChem 115237
PubMed Paliperidone
Kompas (Dutch) Paliperidone
Wikipedia Paliperidone

Switch medication from Olanzapine_LA to Paliperidone.[1] [2]

Nietinrijdenbord.png Stop Olanzapine_LA
  • Day 1: Last depot injection
Eenrichtingbord.png Start Paliperidone
  • Week 1-3: approx. 25% of target dose
  • Week 4-6: approx. 50% of target dose
  • Week 7-9: approx. 75% of target dose
  • Week 10: target dose
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[3]
    StopDepotStartOral.jpg
Nietinrijdenbord.png — Olanzapine_LA
Eenrichtingbord.png — Paliperidone


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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