Difference between revisions of "Paliperidone LP-Paliperidone SP"

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Revision as of 17:09, 18 March 2022

Paliperidone LP
Xeplion® = long acting, 30 days
Type Antipsychotic
Group Atypical AP
links
PubChem 23724979
PubMed LP%22 Paliperidone LP
Kompas (Dutch) Paliperidone LP
Wikipedia Paliperidone LP
Paliperidone SP
Trevicta® = super long acting, 90 days
Type Antipsychotic
Group Atypical AP
links
PubChem 23724979
PubMed SP%22 Paliperidone SP
Kompas (Dutch) Paliperidone SP
Wikipedia Paliperidone SP

Switch medication from Paliperidone_LP to Paliperidone_SP.[1] [2]

Nietinrijdenbord.png Stop Paliperidone_LP
  • Day 1: Last depot injection
Eenrichtingbord.png Start Paliperidone_SP

Start depot on the day you would normally have injected the next depot. Increase the dose of paliperidone SP by 3,5 times the dose of paliperidone LP. Administer every 3 months.

Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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