{{downparox}}* '''Day 1:''' Decrease with about 25% of original dose every 3-4 days
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* '''Day 16:''' start agomelatine in a dosage of 25 mg/day.* '''Day 31:''' If necessary, gradually increase dosage of agomelatine to target dose. {{startAgomelatine}}
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* An extra reduction week to paroxetine 2,5 mg/day is sometimes necessary.* Low doses of paroxetine can be given by a paroxetine-solution.<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>