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Type Antidepressant
Group SSRI
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine
Type Antidepressant
Group NRI
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline

Switch medication from paroxetine to maprotiline.

Nietinrijdenbord.png Stop paroxetine
  • Before day 1: gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
  • Day 1: reduce dosage of paroxetine to a maximum of 10 mg/day.
  • Day 8: stop dosage of paroxetine.
Eenrichtingbord.png Start maprotiline

Caution is necessary.

  • Day 8: start administration of maprotiline in a low dosage of 25 mg/day.
  • Day 15: increase administration of maprotiline to a dosage of 50-100 mg/day.
  • "Start low, go slow" is not required, but caution is necessary!
Infobord.png More information
  • Paroxetine slows the metabolism of maprotiline via CYP1A2 and CYP2D6.
  • This switch is currently being reviewed.
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