Difference between revisions of "Paroxetine-nortriptyline"

From Psychiatrienet
Jump to: navigation, search
Line 3: Line 3:
 
| to = nortriptyline  
 
| to = nortriptyline  
 
| stop =  
 
| stop =  
{{downparox}}
+
{{stopParoxetine}}
 
| start =   
 
| start =   
* '''Day 15:''' start administration of nortriptyline in a low dosage of 25 mg/day.  
+
* '''Day 9:''' start administration of nortriptyline in a low dosage of 25 mg/day.  
* '''Day 22:''' continue nortriptyline in a dosage of 50 mg/day.
+
* '''Day 16:''' continue nortriptyline in a dosage of 50 mg/day.
 
| info =  
 
| info =  
 
* Paroxetine slows the metabolism of nortriptyline via CYP2D6.  
 
* Paroxetine slows the metabolism of nortriptyline via CYP2D6.  
{{review}}
 
 
}}
 
}}

Revision as of 14:13, 28 October 2015

paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine
Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline

Switch medication from paroxetine to nortriptyline.[1] [2]

Nietinrijdenbord.png Stop paroxetine
  • Before day 1: gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
  • Day 1: reduce dosage of paroxetine to a maximum of 10 mg/day.
  • Day 8: stop administration of paroxetine.
Eenrichtingbord.png Start nortriptyline
  • Day 9: start administration of nortriptyline in a low dosage of 25 mg/day.
  • Day 16: continue nortriptyline in a dosage of 50 mg/day.
Infobord.png More information
  • Paroxetine slows the metabolism of nortriptyline via CYP2D6.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.