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Partial agonist-Chlorpromazine

Partial agonists

Aripiprazole
Brexpiprazole
Cariprazine

Chlorpromazine
Type Antipsychotic
Group Phenothiazines
links
Medscape Chlorpromazine
PubChem 2726
PubMed Chlorpromazine
Kompas (Dutch) Chlorpromazine
Wikipedia Chlorpromazine

Switch medication from Partial agonist to Chlorpromazine.[1] [2]
Partial agonist is a collection of antipsychotic drugs having similar properties with respect to switching. A switch to member of the 'partial agonist' group from anotherdrug should be read as partial agonist-anotherdrug. Similarly, a switch from a member of the 'partial agonist' group to anotherdrug should be read as anotherdrug-partial agonist.

Nietinrijdenbord.png Stop Partial agonist
  • Day 1-21: Continue drug at usual dose
  • Day 22: Stop drug
Eenrichtingbord.png Start Chlorpromazine
  • Day 1-4: approx. 25% of target dose
  • Day 5-8: approx. 50% of target dose
  • Day 9-12: approx. 75% of target dose
  • Day 13: target dose
  • Day 28: Reevaluate dose, if necessary adjust dose
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[3]
  • During this switch monitoring of the haematological parameters is necessary.
    StopAbruptly21StartGradually2.jpg
Nietinrijdenbord.png — Partial agonist
Eenrichtingbord.png — Chlorpromazine


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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