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Switch medication from Partial antagonist to Clozapine.[1]
[2]
Partial antagonist is a collection of antipsychotic drugs having similar properties with respect to switching. A switch to member of the 'partial antagonist' group from anotherdrug should be read as partial antagonist-anotherdrug. Similarly, a switch from a member of the 'partial antagonist' group to anotherdrug should be read as anotherdrug-partial antagonist.
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Stop Partial antagonist - Day 1-21: Continue drug at usual dose
- Day 22: Stop drug
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Start Clozapine- Day 1: start with 12,5 mg at night
- Day 2: 25 mg in divided doses
- Day 3-15: increase daily dose every 1-2 day(s) with 25 mg
- Day 16-28: if necessary, increase dose with 50-100 mg/week
- Low dose in the morning, high dose at night (twice daily dosage)
- Increments are dependent on the status of patient
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More information- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[3]
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— Partial antagonistError creating thumbnail: File missing
— Clozapine
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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