Partial antagonist-Rest AP

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Partial antagonist

Aripiprazole
Brexpiprazole
Cariprazine

Rest anti-psychotics

Chlorprothixene
Flupentixol
Loxapine
Pericyazine
Perphenazine
Trifluoperazine
Ziprasidone
Zuclopenthixol

Switch medication from Partial antagonist to Rest AP.[1] [2]
Partial antagonist is a collection of antipsychotic drugs having similar properties with respect to switching. A switch to member of the 'partial antagonist' group from anotherdrug should be read as partial antagonist-anotherdrug. Similarly, a switch from a member of the 'partial antagonist' group to anotherdrug should be read as anotherdrug-partial antagonist.

Nietinrijdenbord.png Stop Partial antagonist
  • Day 1-21: Continue drug at usual dose
  • Day 22: Stop drug
Eenrichtingbord.png Start Rest AP
  • Day 1-4: approx. 25% of target dose
  • Day 5-8: approx. 50% of target dose
  • Day 9-12: approx. 75% of target dose
  • Day 13: target dose
  • Day 28: Reevaluate dose, if necessary adjust dose
Infobord.png More information
StopAbruptly21StartGradually2.jpg
Nietinrijdenbord.png — Partial antagonist
Eenrichtingbord.png — Rest AP


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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