Partial antagonist-Risperidone LA

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Partial antagonist

Aripiprazole
Brexpiprazole
Cariprazine

Risperidone
long acting
Type Antipsychotic
Group Atypical AP
links
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone

Switch medication from Partial antagonist to Risperidone_LA.[1] [2]
Partial antagonist is a collection of antipsychotic drugs having similar properties with respect to switching. A switch to member of the 'partial antagonist' group from anotherdrug should be read as partial antagonist-anotherdrug. Similarly, a switch from a member of the 'partial antagonist' group to anotherdrug should be read as anotherdrug-partial antagonist.

Nietinrijdenbord.png Stop Partial antagonist
  • Week 1-5: Continue drug at usual dose
  • Week 6: Stop drug
Eenrichtingbord.png Start Risperidone_LA
  • Day 1: Start depot according general dosing advice (Dotted line in graph)
Infobord.png More information
  • Cognitive functions could improve after this switch.[3]
    StopArip6WeeksStartDepotRisp.jpg
Nietinrijdenbord.png — Partial antagonist
Eenrichtingbord.png — Risperidone_LA


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Kim SW et al. Effects of switching to long-acting injectable risperidone from oral atypical antipsychotics on cognitive function in patients with schizophrenia.. Hum Psychopharmacol. 2009 Oct;24(7):565-73.
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