* '''Before day 0:''' gradually reduce dosage of sertraline to a maximum of 50 mg/day, when this dosage is > 50 mg/day. {{TCAdecrease25p3d}}* '''Day 1:''' reduce dosage of sertraline to 25 mg/day.* '''Day 8:''' stop administration of sertraline.| start = {{StartAgomelatine|15}}| start info= * '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.* '''Day 8:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day. }}