* '''Before day 1:''' gradually reduce dosage of sertraline to a maximum of 100 mg/day, when this dosage is > 100 mg/day. * '''Day 1:''' reduce dosage of sertraline to 50 mg/day.* '''Day 8:''' reduce dosage of sertraline to 25 mg/day.* '''Day 15:''' stop administration of sertraline.{{TCAdecrease25p3d}}| start = * '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.* '''Day 15:''' continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day. <ref name="agoswitch"> {{PubmedStartAgomelatine|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-10215}}</ref>