Sertraline-amitriptyline

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Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from sertraline to amitriptyline.[1] [2]

Nietinrijdenbord.png Stop sertraline
  • Before day 1: gradually reduce dosage of sertraline to a maximum of 50 mg/day when this dosage is > 50 mg/day.
  • Day 1: reduce dosage of sertraline to a maximum of 25 mg/day.
  • Day 8: stop administration of sertraline.
Eenrichtingbord.png Start amitriptyline

Caution is necessary.

  • Day 1: simultaneously start administration of amitriptyline in a low dosage of 25 mg/day.
  • Day 8: continue administration of amitriptyline in a dosage of 50 mg/day.
  • Start low, go slow!
Infobord.png More information
  • Sertraline dose-dependently slows the metabolism of amitriptyline via CYP2D6.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • This switch is currently being reviewed.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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