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Sertraline-mianserine

Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline
Mianserine
Type Antidepressant
Group other
links
PubChem 4184
PubMed Mianserine
Kompas (Dutch) Mianserine
Wikipedia Mianserine

Switch medication from sertraline to mianserine.[1] [2]

Nietinrijdenbord.png Stop sertraline
  • Before day 1: gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
  • Day 1: reduce dosage of sertraline to 25 mg/day.
Eenrichtingbord.png Start mianserine
  • Day 1: simultaneously start administration of mianserine in a low dosage of 30 mg/day for one week.
  • Day 8: stop administration of sertraline and continue administration of mianserine only.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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