| to = nortriptyline
| stop =
* '''Before day 1:''' gradually reduce dosage of sertraline to a maximum of 50 mg/ day when this dosage is > 50 mg/day. * '''Day 1:''' reduce dosage of sertraline to a maximum of 25 mg/day.{{TCAdecrease25p3d}}| start = * '''Day 1:''' simultaneously start administration of nortriptyline in a low dosage of 25 mg/day.* '''Day 8:''' stop administration of sertraline and continue administration of nortriptyline in a dosage of 50 mg/day* “Start low, go slow” is not required, but caution is necessary.{{TCAincrease25p3d}}| info = Sertraline dose-dependently slows the metabolism of nortriptyline via CYP2D6. {{TCAplasmalevelmonitoring}}}}