* '''Before day 0:''' gradually reduce dosage of sertraline to a maximum of 25 mg/day, when this dosage is > 25 mg/day. {{generaldecrease25p3d}}{{7dWashout}}* '''Day 1:''' stop administration of sertraline.| start = * '''Day 1-7:''' a wash-out period of one week 7 days is necessary.* '''Day 8:''' start tranylcypromine the next day in a normal dosage of 20 mg/day.{{Starttranyl}}| info caveat = * A switch from sertraline to tranylcypromine is not obvious, given the necessary prolonged wash-out period in this case.{{caveSS}}* Occurrence of serotonin syndrome is reported when a wash-out period (of one week) is not considered.}}