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Type Antidepressant
Group SSRI
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline
Type Antidepressant
Group MAO-I
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Wikipedia Tranylcypromine

Switch medication from sertraline to tranylcypromine.

Nietinrijdenbord.png Stop sertraline
  • Before day 0: gradually reduce dosage of sertraline to a maximum of 25 mg/day, when this dosage is > 25 mg/day.
  • Day 1: stop administration of sertraline.
Eenrichtingbord.png Start tranylcypromine
  • Day 1-7: a wash-out period of one week is necessary.
  • Day 8: start tranylcypromine the next day in a normal dosage of 20 mg/day for one week.
  • Day 15: after this week the dosage of tranylcypromine can be increased if necessary.
Infobord.png More information
  • A switch from sertraline to tranylcypromine is not obvious, given the necessary prolonged wash-out period in this case.
  • Occurrence of serotonin syndrome is reported when a wash-out period (of one week) is not considered.
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