* '''Day 1:''' start with 12,5mg at night* '''Day 2-15:''' increase daily dose every 1-2 day(s) with 25 mg * '''Day 316-28:''' if necessary, increase dose to with 50 -100 mg/week* '''Day 5-15:''' increase dose daily with 25mg* '''Day 18:''' increase low dose with 50mg* '''Day 21:''' increase in the morning, high dose with 50mgat night (twice daily)* '''Day 28:''' increase dose with 50mgincrements are dependent on the status of patient