| to = agomelatine
| stop =
* '''Before day 0:''' gradually reduce dosage of tranylcypromine to a maximum of 40 mg/day, when this dosage is > 40 mg/day. * '''Day 1:''' reduce dosage of tranylcypromine to 20 mg/day.* '''Day 8:''' reduce dosage of tranylcypromine to 10 mg/day.* '''Day 15:''' stop administration of tranylcypromine.{{stopTranyl}}
| start =
* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.* '''Day 15:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day. {{startAgomelatine}}
| info =
{{Tcrestore}}<ref name="informatorium">{{KNMP|tranylcypromine}}</ref> * Tranylcypromine has to be phased out to avoid withdrawal symptoms.<ref>Dr. M.J.Blom et al. (2009) Gebruik van klassieke MAO-remmers</ref> * Because tranylcypromine is a irriverible MAO inhibitor, the activity of MAO enzymes will be normal after two weeks.
}}