Difference between revisions of "Tranylcypromine-agomelatine"

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* '''Day 15:''' stop administration of tranylcypromine.
 
* '''Day 15:''' stop administration of tranylcypromine.
 
| start =  
 
| start =  
* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.
+
* '''Day 15-28:''' a wash-out period of one week is necessary.
* '''Day 15:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.  
+
* '''Day 29:''' start administration of agomelatine in a dosage of 25 mg/day.
 +
* If necessary, increase dosage of agomelatine to 50 mg/day.  
 
| info =  
 
| info =  
 
* Tranylcypromine has to be phased out to avoid withdrawal symptoms.
 
* Tranylcypromine has to be phased out to avoid withdrawal symptoms.
 
* Because tranylcypromine is a irriverible MAO inhibitor, the activity of MAO enzymes will be normal again after two weeks.
 
* Because tranylcypromine is a irriverible MAO inhibitor, the activity of MAO enzymes will be normal again after two weeks.
}}
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* Occurrence of the serotonin syndrome is theoretically possible.}}

Revision as of 09:39, 8 May 2009

Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine
Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine

Switch medication from tranylcypromine to agomelatine.[1] [2]

Nietinrijdenbord.png Stop tranylcypromine
  • Before day 0: gradually reduce dosage of tranylcypromine to a maximum of 40 mg/day, when this dosage is > 40 mg/day.
  • Day 1: reduce dosage of tranylcypromine to 20 mg/day.
  • Day 8: reduce dosage of tranylcypromine to 10 mg/day.
  • Day 15: stop administration of tranylcypromine.
Eenrichtingbord.png Start agomelatine
  • Day 15-28: a wash-out period of one week is necessary.
  • Day 29: start administration of agomelatine in a dosage of 25 mg/day.
  • If necessary, increase dosage of agomelatine to 50 mg/day.
Infobord.png More information
  • Tranylcypromine has to be phased out to avoid withdrawal symptoms.
  • Because tranylcypromine is a irriverible MAO inhibitor, the activity of MAO enzymes will be normal again after two weeks.
  • Occurrence of the serotonin syndrome is theoretically possible.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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