Tranylcypromine-agomelatine

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Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine
Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine

Switch medication from tranylcypromine to agomelatine.[1] [2]

Nietinrijdenbord.png Stop tranylcypromine
  • Day 1: Decrease the original dose with about 25% every 3 days.
Eenrichtingbord.png Start agomelatine
  • Day 15: Start and increase the dose with about 25% of the target dose every 3 days or 50% per week.[3]
Infobord.png More information
  • Tranylcypromine has to be phased out to avoid withdrawal symptoms.
  • After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. KNMP; Informatorium Medicamentorum 2023; Monografie "tranylcypromine" (Dutch)
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