Difference between revisions of "Tranylcypromine-bupropion"

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(Created page with '{{Drugswitch | from = tranylcypromine | to = bupropion | stop = * Gradually decrease the dosage of tranylcypromine with 10-20 mg/week. * When a dosage of 10 mg/day is reached...')
 
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* '''Day 15:''' start bupropion after this period in a normal dosage of 150 mg/day.
 
* '''Day 15:''' start bupropion after this period in a normal dosage of 150 mg/day.
 
| info =  
 
| info =  
* Occurence of the serotonin syndrome is theoretically possible.
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* Occurence of the serotonin syndrome is possible without a wash-out period.
 
* The wash-out period is necessary for the MAO enzymes to restore their function.}}
 
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Revision as of 13:52, 8 May 2009

Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine
Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion

Switch medication from tranylcypromine to bupropion.[1] [2]

Nietinrijdenbord.png Stop tranylcypromine
  • Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
  • When a dosage of 10 mg/day is reached, stop administration.
Eenrichtingbord.png Start bupropion
  • Day 1-14: a wash-out period of two weeks is necessary.
  • Day 15: start bupropion after this period in a normal dosage of 150 mg/day.
Infobord.png More information
  • Occurence of the serotonin syndrome is possible without a wash-out period.
  • The wash-out period is necessary for the MAO enzymes to restore their function.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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