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Psychiatrienet β


Type Antidepressant
Group MAO-I
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine
Type Antidepressant
Group SSRI
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram

Switch medication from tranylcypromine to citalopram.[1] [2]

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Stop tranylcypromine
  • Day 1: decrease the original dose with about 25% every 3 days.
  • Day 9: stop administration of tranylcypromine.
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Start citalopram
  • Day 28: Start and increase the dose with about 50% of the target dose per week. [3]
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More information
  • After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes
  • Occurrence of the serotonin syndrome is possible without this wash-out period.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. KNMP; Informatorium Medicamentorum 2023; Monografie "tranylcypromine" (Dutch)
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