Difference between revisions of "Tranylcypromine-moclobemide"

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| to = moclobemide
 
| to = moclobemide
 
| stop =  
 
| stop =  
* Decrease the original dose with about 25% every 3 days.  
+
* '''Day 1:''' Decrease the original dose with about 25% every 3 days.  
* When a dosage of 10 mg/day is reached, stop administration.
+
 
 
| start =   
 
| start =   
* '''Day 1-14:''' a wash-out period of two weeks is necessary.  
+
* '''Day 1:''' Increase the dose with about 50% of the target dose per week.  
* '''Day 15:''' start moclobemide after this period in a normal dosage of 300 mg/day.
+
 
 
| info =  
 
| info =  
* The wash-out period is necessary for the MAO enzymes to restore their function.}}
+
* Even after the last dose of tranylcypromine it takes about 2 weeks to restore the activity of the MAO enzymes.}}

Revision as of 13:45, 5 October 2015

Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine
Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide

Switch medication from tranylcypromine to moclobemide.[1] [2]

Nietinrijdenbord.png Stop tranylcypromine
  • Day 1: Decrease the original dose with about 25% every 3 days.
Eenrichtingbord.png Start moclobemide
  • Day 1: Increase the dose with about 50% of the target dose per week.
Infobord.png More information
  • Even after the last dose of tranylcypromine it takes about 2 weeks to restore the activity of the MAO enzymes.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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