Difference between revisions of "Trazodone-clomipramine"
From Psychiatrienet
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| to = clomipramine | | to = clomipramine | ||
| stop = | | stop = | ||
| − | + | {{stopTrazodone}} | |
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| start = | | start = | ||
| − | No wash-out period is needed. | + | * No wash-out period is needed. |
| − | * '''Day | + | * '''Day 9:''' start administration of clomipramine in a dosage of 50 mg/day. |
| − | * '''Day | + | * '''Day 16:''' increase dosage of clomipramine to 75 mg/day. |
* Start low, go slow. | * Start low, go slow. | ||
| info = | | info = | ||
| − | * | + | * {{theorSS}} |
| − | + | {{trazoTablet}} | |
| − | {{ | + | }} |
Revision as of 14:09, 4 November 2015
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Switch medication from trazodone to clomipramine.[1] [2]
Stop trazodone - Before day 1: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
- Day 1: reduce dosage of trazodone to 100 mg/day.
- Day 4: stop administration of trazodone.
Start clomipramine- No wash-out period is needed.
- Day 9: start administration of clomipramine in a dosage of 50 mg/day.
- Day 16: increase dosage of clomipramine to 75 mg/day.
- Start low, go slow.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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