Difference between revisions of "Trazodone-doxepine"

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{{stopTrazodone}}
 
{{stopTrazodone}}
 
| start =  
 
| start =  
No wash-out period is needed.
+
* No wash-out period is needed.
 
* '''Day 1:''' simultaneously start administration of doxepin in a dosage of 25 mg/day.  
 
* '''Day 1:''' simultaneously start administration of doxepin in a dosage of 25 mg/day.  
 
* '''Day 8:''' stop administration of trazodone and continue administration of doxepin in a dosage of 50 mg/day.  
 
* '''Day 8:''' stop administration of trazodone and continue administration of doxepin in a dosage of 50 mg/day.  

Revision as of 13:07, 4 November 2015

Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone
Doxepin
Type antidepressant
Group TCA
links
ATC-code N06AA12
Medscape Doxepin
PubChem 3158
PubMed Doxepin
Drugs.com doxepin
Kompas (Dutch) Doxepin
Wikipedia Doxepin

Switch medication from trazodone to doxepin.[2] [3]

Nietinrijdenbord.png Stop trazodone
  • Before day 1: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
  • Day 1: reduce dosage of trazodone to 100 mg/day.
  • Day 4: stop administration of trazodone.
Eenrichtingbord.png Start doxepin
  • No wash-out period is needed.
  • Day 1: simultaneously start administration of doxepin in a dosage of 25 mg/day.
  • Day 8: stop administration of trazodone and continue administration of doxepin in a dosage of 50 mg/day.
  • Start low, go slow.
Infobord.png More information
  • The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
  1. 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
  2. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  3. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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