Revision as of 15:54, 2 November 2015 by Anoek
Switch medication from trazodone to duloxetine.
- Before day 1: gradually reduce dosage of trazodone to a maximum of 100-150 mg/day, when this dosage is > 200 mg/day.
- Day 1: reduce dosage of trazodone to 75 mg or maintain on 100 mg/day.
- Day 8: stop administration of trazodone.
- A wash-out period is not necessary, but care is needed.
- Day 8: start administration of duloxetine in a normal dosage of 60 mg/day.
- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Duloxetine is a strong inhibitor of CYP2D6, which metabolizes trazodone.
- The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
- This switch is currently being reviewed.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.