Difference between revisions of "Trazodone-maprotiline"

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* Start low, go slow.
 
* Start low, go slow.
 
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* The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.  }}
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* The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.  
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{{review}}
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Revision as of 14:56, 2 November 2015

Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone
Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline

Switch medication from trazodone to maprotiline.[1] [2]

Nietinrijdenbord.png Stop trazodone
  • Before day 1: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
  • Day 1: reduce dosage of trazodone to 75-100 mg/day.
  • Day 8: stop administration of trazodone.
Eenrichtingbord.png Start maprotiline

No wash-out period is needed.

  • Day 1: simultaneously start administration of maprotiline in a dosage of 25 mg/day.
  • Day 8: stop administration of trazodone and continue administration of maprotiline in a dosage of 50 mg/day.
  • Start low, go slow.
Infobord.png More information
  • The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
  • This switch is currently being reviewed.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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