| stop = * '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day{{StopSSRI, when this dosage is > 150 mg/day. * '''Day 1:''' reduce dosage of trazodone to 75 mg/day.* '''Day 8:''' stop administration of trazodone.SNRI}}| start = {{StartAntidepressant}}* A wash-out period is not necessary, but care is needed.| info =* '''Day 8:''' start administration of Safe target dose sertraline in a normal dosage of = 50 mg/day.| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}* Sertraline dose-dependently inhibits CYP2D6, which metabolizes trazodone.}}