Difference between revisions of "Trazodone-tranylcypromine"

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| to = tranylcypromine  
 
| to = tranylcypromine  
 
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* '''Before day 1:'''  gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
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{{stopTrazodone}}
* '''Day 1:''' reduce dosage of trazodone to 100 mg/day.
 
* '''Day 3:''' reduce dosage of trazodone to 50 mg/day.
 
* '''Day 8:''' stop administration of trazodone.
 
 
| start =  
 
| start =  
 
* '''Day 8-10:''' a wash-out period of 3 days is necessary.
 
* '''Day 8-10:''' a wash-out period of 3 days is necessary.
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* If necessary, increase dosage of tranylcypromine.  
 
* If necessary, increase dosage of tranylcypromine.  
 
| info =  
 
| info =  
* Occurrence of the serotonin syndrome is theoretically possible, so care is needed.
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* {{theorSS}}
* The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given. 
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Revision as of 14:02, 22 September 2016

Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone
Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine

Switch medication from trazodone to tranylcypromine.[1] [2]

Nietinrijdenbord.png Stop trazodone
  • Before day 1: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
  • Day 1: reduce dosage of trazodone to 100 mg/day.
  • Day 4: stop administration of trazodone.
Eenrichtingbord.png Start tranylcypromine
  • Day 8-10: a wash-out period of 3 days is necessary.
  • Day 11: start administration of tranylcypromine in a dosage of 20 mg/day.
  • If necessary, increase dosage of tranylcypromine.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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