Difference between revisions of "Trazodone-vortioxetine"

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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
 
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Revision as of 14:58, 2 November 2015

Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone
Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine

Switch medication from trazodone to vortioxetine.[1] [2]

Nietinrijdenbord.png Stop trazodone
  • Before day 1: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
  • Day 1: reduce the dosage of trazodone to 75-100 mg/day.
  • Day 8: when a dosage of 75 mg/day is reached, stop administration
Eenrichtingbord.png Start vortioxetine
  • A wash-out period is not necessary.
  • Day 8: start administration of vortioxetine in a normal dosage of 10 mg/day.
Infobord.png More information
  • Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
  • This switch is currently being reviewed.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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