| to = maprotiline
| stop =
* '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.* '''Day 1:''' reduce a dosage of 75 mg/day to 37,5 mg/day.{{TCAdecrease25p3d}}
| start =
* '''Day 1:''' simultaneously start administration of maprotiline in a low dosage of 25-75 mg/day.* '''Day 8:''' stop administration of venlafaxine and continue administration of maprotiline.{{TCAincrease25p3d}}| info = * “Start low, go slow” is not required, but caution with this switch is necessary. {{TCAplasmalevelmonitoring}}* Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes maprotiline.}}