Switch medication from Vortioxetine to agomelatine.
- Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
- Day 9: start administration of agomelatine in a dosage of 25 mg/day.
- Day 23: if necessary, increase dosage of agomelatine to 50 mg/day.
- More information: see references  
- McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
- Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54
- KNMP; Informatorium Medicamentorum 2015; Monografie "vortioxetine" (Dutch)
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