Difference between revisions of "Vortioxetine-amitriptyline"

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* '''Day 8:''' continue administration of amitriptyline in a dosage of 50 mg/day.  
 
* '''Day 8:''' continue administration of amitriptyline in a dosage of 50 mg/day.  
 
* Start low, go slow.
 
* Start low, go slow.
 +
| info =
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* {{theorSS}}
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}}

Revision as of 09:04, 19 February 2015

Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from vortioxetine to amitriptyline.[1] [2]

Nietinrijdenbord.png Stop vortioxetine
  • Day 1: stop administration of vortioxetine.
Eenrichtingbord.png Start amitriptyline

No wash-out period is needed.

  • Day 1: simultaneously start administration of amitriptyline in a dosage of 25 mg/day.
  • Day 8: continue administration of amitriptyline in a dosage of 50 mg/day.
  • Start low, go slow.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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