Difference between revisions of "Vortioxetine-amitriptyline"

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* '''Day 9:''' start administration of amitriptyline in a dosage of 25 mg/day.  
 
* '''Day 9:''' start administration of amitriptyline in a dosage of 25 mg/day.  
 
* '''Day 16:''' continue administration of amitriptyline in a dosage of 50 mg/day.  
 
* '''Day 16:''' continue administration of amitriptyline in a dosage of 50 mg/day.  
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{{Day22NoBloodlevelvortioxetine}} <ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref>
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| info =
 
* {{theorSS}}
 
* {{theorSS}}
 
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Revision as of 14:53, 4 November 2015

Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from vortioxetine to amitriptyline.[1] [2]

Nietinrijdenbord.png Stop vortioxetine
  • Day 1: reduce dosage of vortioxetine to 5 mg/day.
  • Day 8: stop administration of vortioxetine.
Eenrichtingbord.png Start amitriptyline
  • No wash-out period is needed.
  • Day 9: start administration of amitriptyline in a dosage of 25 mg/day.
  • Day 16: continue administration of amitriptyline in a dosage of 50 mg/day.
  • Day 22: bloodlevel vortioxetine is now zero, so you can increase faster. [3] [4]
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54
  4. KNMP; Informatorium Medicamentorum 2023; Monografie "vortioxetine" (Dutch)
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