Difference between revisions of "Vortioxetine-citalopram"

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| to = citalopram
 
| to = citalopram
 
| stop =  
 
| stop =  
* '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.
+
{{stopVortioxetine}}
* '''Day 7:''' stop administration of vortioxetine.
 
 
| start =  
 
| start =  
 
* No wash-out period is needed.  
 
* No wash-out period is needed.  
* '''Day 8:''' Start citalopram in a normal dosage of 20 mg/day.
+
* '''Day 9:''' Start citalopram in a normal dosage of 20 mg/day.
 
| info =
 
| info =
 
* {{theorSS}}<ref>[http://www.ema.europa.eu/docs/nl_NL/document_library/EPAR_-_Product_Information/human/002717/WC500159449.pdf European Medicines Agency. SmPC Brintellix 5 mg.]</ref>
 
* {{theorSS}}<ref>[http://www.ema.europa.eu/docs/nl_NL/document_library/EPAR_-_Product_Information/human/002717/WC500159449.pdf European Medicines Agency. SmPC Brintellix 5 mg.]</ref>
* because of halflifes of both compunds, there will be automatic crosstapering in the body.
+
{{AutomaticCrosstapering}}<ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref>
 
}}
 
}}

Revision as of 15:03, 4 November 2015

Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine
Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram

Switch medication from vortioxetine to citalopram.[1] [2]

Nietinrijdenbord.png Stop vortioxetine
  • Day 1: reduce dosage of vortioxetine to 5 mg/day.
  • Day 8: stop administration of vortioxetine.
Eenrichtingbord.png Start citalopram
  • No wash-out period is needed.
  • Day 9: Start citalopram in a normal dosage of 20 mg/day.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.[3]
  • Due to the halflifes of both compounds, there will be automatic crosstapering in the body.[4] [5]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. European Medicines Agency. SmPC Brintellix 5 mg.
  4. Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54
  5. KNMP; Informatorium Medicamentorum 2023; Monografie "vortioxetine" (Dutch)
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