Difference between revisions of "Vortioxetine-dosulepine"

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* '''Day 7:''' stop administration of vortioxetine.
 
* '''Day 7:''' stop administration of vortioxetine.
 
| start =  
 
| start =  
* '''Day 8:''' start administration of dosulepine in a normal dosage of 50-75 mg/day.
+
* '''Day 8:''' start administration of dosulepine with 25 mg/day.
* '''Day 15:''' increase dosage of dosulepine if necessary.
+
{{GoSlow}}
 
| info =  
 
| info =  
* “Start low, go slow” for dosulepine is not required, but caution is necessary.
 
 
* {{theorSS}}<ref>[[European Medicines Agency]] | SmPC Brintellix 5 mg. </ref>
 
* {{theorSS}}<ref>[[European Medicines Agency]] | SmPC Brintellix 5 mg. </ref>
 
}}
 
}}

Revision as of 17:03, 11 March 2015

Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine
dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin

Switch medication from vortioxetine to dosulepine.[1] [2]

Nietinrijdenbord.png Stop vortioxetine
  • Day 1: reduce dosage of vortioxetine to 5 mg/day.
  • Day 7: stop administration of vortioxetine.
Eenrichtingbord.png Start dosulepine
  • Day 8: start administration of dosulepine with 25 mg/day.
  • Titrate slowly
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. European Medicines Agency | SmPC Brintellix 5 mg.
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