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Vortioxetine-dosulepine

Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine
dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin

Switch medication from vortioxetine to dosulepine.[1] [2]

Nietinrijdenbord.png Stop vortioxetine
  • Day 1: Stop vortioxetine
  • vortioxetine can be stopped abruptly[3] [4]
Eenrichtingbord.png Start dosulepine
  • Day 1: Increase with about 25% of target dose per 3 days.
Infobord.png More information
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[5]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. CBG meb, accessed june 2023, SmPC Vortioxetine
  4. Multidisciplinair document Afbouwen Overige Antidepressiva 2023
  5. (dutch) monografie.org tricyclische-antidepressiva
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