| stop = * '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.* '''Day 7:''' stop administration of vortioxetine.{{StopSSRI,SNRI}}| start = {{StartAntidepressant}}* '''Day 8:''' start administration of duloxetine in a normal dosage of 30-60 mg/day.| info =* '''Day 15:''' increase the dosage of Safe target dose duloxetine if needed.| info = <ref>[[European Medicines Agency]] | SmPC Brintellix 5 60 mg. </ref>* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}* Duloxetine is a inhibitor of CYP2D6, which metabolizes vortioxetine.}}