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| from = vortioxetine
| to = duloxetine
| stop = {{StopSSRI,SNRI}}* '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.* '''Day 7:''' stop administration of vortioxetine.| start = {{StartAntidepressant}}| start info = * '''Day 8:''' start administration of Safe target dose duloxetine in a normal dosage of 30-= 60 mg/day.* '''Day 15:''' increase the dosage of duloxetine if needed.| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}* Duloxetine is a inhibitor of CYP2D6, which metabolizes vortioxetine.<ref>[[European Medicines Agency]] | SmPC Brintellix 5 mg. </ref>}}